FluBlok, a recombinant hemagglutinin influenza vaccine
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منابع مشابه
FluBlok, a recombinant hemagglutinin influenza vaccine
FluBlok, a recombinant trivalent hemagglutinin (HA) vaccine produced in insect cell culture using the baculovirus expression system, provides an attractive alternative to the current egg-based trivalent inactivated influenza vaccine (TIV) manufacturing process. FluBlok contains three times more HA than TIV and does not contain egg-protein or preservatives. This review discusses the four main cl...
متن کاملProtective efficacy of a trivalent recombinant hemagglutinin protein vaccine (FluBlok®) against influenza in healthy adults: a randomized, placebo-controlled trial.
BACKGROUND Development of influenza vaccines that do not use embryonated eggs as the substrate for vaccine production is a high priority. We conducted this study to determine the protective efficacy a recombinant, baculovirus-expressed seasonal trivalent influenza virus hemagglutinin (rHA0) vaccine (FluBlok(®)). METHODS Healthy adult subjects at 24 centers across the US were randomly assigned...
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Introduction Flublok is the first recombinant hemagglutinin (rHA) vaccine licensed in the US by FDA for the prevention of influenza in adults 18 and older. The rHAs are produced in insect cell culture using the baculovirus expression vector system (BEVS) technology, and are, in contrast to HAs from viruses adapted to growth in hen’s eggs, an exact genetic match to the HAs of the influenza strai...
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Abstract Background and Aims: Influenza A(H5N1) viruses circulating in animals might evolve and acquire the ability to spread from human to human and thus start a pandemic. Hemagglutinin (HA) has been shown to play a major role in binding of influenza virus to its target cell and the main neutralizing antibody responses elicit against this region. Recent studies have shown that...
متن کاملPre-Clinical Evaluation of a Replication-Competent Recombinant Adenovirus Serotype 4 Vaccine Expressing Influenza H5 Hemagglutinin
BACKGROUND Influenza virus remains a significant health and social concern in part because of newly emerging strains, such as avian H5N1 virus. We have developed a prototype H5N1 vaccine using a recombinant, replication-competent Adenovirus serotype 4 (Ad4) vector, derived from the U.S. military Ad4 vaccine strain, to express the hemagglutinin (HA) gene from A/Vietnam/1194/2004 influenza virus ...
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ژورنال
عنوان ژورنال: Influenza and Other Respiratory Viruses
سال: 2008
ISSN: 1750-2640
DOI: 10.1111/j.1750-2659.2008.00053.x